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Fontana pointed out that obviously hormone and you may growth activities play a primary role inside modulating aging inside the humans. A comparable transform which have been noticed in human beings (we.elizabeth., reduced pain, insulin, and you can complete testosterone) also occur in mice, rats, and you will primates, with one essential difference. During the mice, long-term CR reduces serum IGF-step one concentration from the forty percent (Breece et al., 1991) 